Our research focuses on membrane dynamics and intracellular protein/vesicle traffickings in the epithelial cells. To address these questions, we use epididymis, kidney and peritoneum as our model systems.
Our specific interests are to understand how protein and vesicle movements affect (1) fertilization processes in mammals and (2) disease progression related to kidney dysfunction and peritoneal fibrosis, and how these processes are being regulated in vivo. In our lab, we apply multidisciplinary approaches including (1) 2D polarized and 3D cyst culture, (2) biochemical analyses, (3) animal models (mouse and pig models), (4) proteomics, (5) ex vivo organ culture and co-culture systems (6) advanced imaging systems (including live cell imaging, light-sheet microscopy, electron microscopy) to study membrane activities.
Our lab locates in the main campus of National Taiwan University in Taipei (Veterinary Medicine Bldg.1, Room 306-307, School of Veterinary Medicine, No. 1, Sect. 4, Roosevelt Rd., Taipei 10617, Taiwan)
(address to PS Jason Tsai)
+886 2 33661290 (office, lab)