JT LAB
Conservation Reproductive Biology
&
Regenerative Medicine
National Taiwan Univerity
School of Veterinary Medicine
2024
54. Tzu-Chien Kuo, Wei-Li Hsu, Vin-Cent Wu, Tong-Rong JAN, Pei-Shiue Tsai and Ya-Jane
Lee*. Urinary angiotensin-converting enzyme 2 and its activity in cats with chronic kidney
disease. Frontiers in Veterinary Science. 2024, (SCI).​​
​
53. Shih-Yun Chen, Tse-En Wang, Wei-Yun Lee, Ya-Yi Yang, Hong-Chun Lai, Fuko
Matsuda, Haruhiko Kosek, You-Tzung Chen, Sheng-Hsiang Li, Pei-Shiue Tsai*. Cre-LoxP
And Tamoxifen-Induced Deletion of Ovarian Quiescin Sulfhydryl Oxidase 2 Showed
Disruption of Ovulatory Activity in Mice. Journal of Ovarian Research. 2024,
17(1):66. (SCI).
https://pubmed.ncbi.nlm.nih.gov/38504307/
​
2023
52. Ahmad Rasul Radzali, Chen Hui Cheng, Rozanaliza Radzi, Michelle Fong Wai Cheng,
Adila Mohamad Jaafar, Pei-Shue Tsai, Mokrish Ajat*. Preparation and Characterization
of Gellan Gum Hydrogel as Therapeutic Protein Delivery for Wound Healing. Malaysian
Journal of Fundamental and Applied Sciences. 2023, Accepted (SCI)
51. Yu-Syuan Wei, Yu-Liang Chen, Wei-Yun Lee, Ya-Yi Yang, Sung-Jan Lin, Ching-Ho Wu,
Jiue-In Yang, Tse-En Wang, Jiashing Yu*, Pei-Shiue Tsai*. Antioxidant Nanoparticles
Restore Cisplatin-Induced Male Fertility Defects By Promoting MDC1-53bp1-Associated
Non-homologous DNA Repair Mechanism And Sperm Intracellular Calcium Influx.
International Journal of Nanomedicine. 2023, 18:4313-4327. (SCI)
https://pubmed.ncbi.nlm.nih.gov/37576465
​
50. Wendy Yang, Szu-Chieh Chen, Tse-En Wang, Pei-Shiue Tsai, Pei-Lung Chen. L1cam
alternative shorter transcripts encoding the extracellular domains were overexpressed in the intestine of L1cam knockdown mice. Gene. 2023, 881:147643. (SCI)
https://pubmed.ncbi.nlm.nih.gov/37453721/
​
2022
49. Yu-Syuan Wei, Hui-Ping Cheng, Chin-Ho Wu, Yen-Chen Chang, Ruo-Wei
Lin, Yu-Ting Hsu, Yi-Ting Chen, Shuei-Liong Lin, Su-Yi Tsai, Shinn-Chih Wu,
Pei-Shiue Tsai. Oxidative Stress-Induced Alterations of Cellular Localization and
Expression of Aquaporin 1 Lead to Defected Water Transport Upon Peritoneal
Fibrosis. Biomedicines. 2022, 10(4), 810, March 30 (SCI)
https://pubmed.ncbi.nlm.nih.gov/35453560/
​
48. Yu-Syuan Wei, Wan-Jen Lin, Tse-En Wang, Wei-Yun Lee, Sheng-Hsiang Li, Fu-Jung Lin, Brett Nixon, Petra Sipilä, Pei-Shiue Tsai*, Polarized Epithelium-Sperm Co-Culture
System Revealed Stimulatory Factors for the Secretion of Mouse Epididymal Quiescin
Sulfhydryl Oxidases 1. Journal of Reproduction and Development 2022, Feb. 26
(SCI).
https://pubmed.ncbi.nlm.nih.gov/35228412/
​
2021
47.Tse-En Wang, Ling-Yu Yeh, Robert Kuo-Kuang Lee, Chung-Hao Lu, Tsung-Hsien Yang,
Yu-Wen Kuo, Radhika Joshi, Pei-Shiue Tsai*, Sheng-Hsiang Li*. Secretory mouse quiescin
sulfhydryl oxidase 1 aggregates defected human and mouse spermatozoa in vitro and in
vivo. iScience 2021, Oct. 22 24(10)103167 (SCI).
https://pubmed.ncbi.nlm.nih.gov/34667943/
46.Tse-En Wang, Shiori Minabe, Fuko Matsuda, Sheng-Hsiang Li, Hiroko Tsukamura, Kei-
Ichiro Maeda, Lee Smith, Laura O’Hara, Bart M. Gadella, Pei-Shiue Tsai* Testosterone
regulation on quiescin sulfhydryl oxidase 2 synthesis in the epididymis. Reproduction
2021 April 20th 161(5):593-602 (SCI).
https://pubmed.ncbi.nlm.nih.gov/33784244/
45. Sze-Min Chan, Hui-Wen Chang, Pei-Shiue Tsai, Chian-Ren Jeng, Hao Lee, Yi-Ying Wu,
Chung-Tien Lin*. Clinical and Histopathological Features of Scopolamine Hydrobromide
Induced Dry Eye Syndrome in Sprague-Dawley Rats. Taiwanese Journal of
Veterinary Medicine 2021. Feb. 23rd
https://www.worldscientific.com/doi/10.1142/S1682648520500134
​
44. Ou, Chung-Mao; Lee, Robert Kuo-Kuang; Lin, Ming-Huei; Lu, Chung-Hao; Yang, Tsung-
Hsien; Yeh, Ling-Yu; Tsai, Pei-Shiue Jason; Li, Sheng-Hsiang. A mouse seminal vesicle-
secreted lysozyme c-like protein modulates sperm capacitation. Journal of Cellular
Biochemistry 2021. Jan. 19th (SCI)
https://pubmed.ncbi.nlm.nih.gov/33469950/
​
2020
43. Yu-Hsin Chen, Chean-Ping Wu, Hsiu-Lien Lin, Ren-Bao Liaw, Yung-Yu Lai, Ming-Chen Wu, Lih-Ren Chen and Pei-Shiue Tsai*. Tetrazolium Salt WST-8 as a Novel and Reliable
Chromogenic Indicator for the Assessment of Boar Semen Quality. Animals 2020 Dec.
4th 10(12):2293 (SCI).
https://pubmed.ncbi.nlm.nih.gov/33291566/
​
42. Yu-Jia Chang, Jane-Fang Yu, Tse-En Wang, Shih-Chien Chin, Yu-Syuan Wei, Ting-Yu
Chen, Pei-Shiue Tsai*. Investigation of Epididymal Proteins and General Sperm
Membrane Characteristics of Formosan Pangolin (Manis pentadactyla pentadactyla).
BMC Zoology 2020 Oct. 10th 5:15 (SCI).
https://pubmed.ncbi.nlm.nih.gov/
​
41. Yu-Hsin Chen, Jane-Fang Yu, Yu-Chia Chang, Shih-Chien Chin, Lih-Chiann Wang, Hsiu-
Lien Lin and Pei-Shiue Tsai*. Novel Low-Voltage Electro-ejaculation Approach for Sperm
Collection From Zoo Captive Lanyu Miniature Pigs (Sus barbatus sumatranus). Animals
2020. Oct. 7th 10:(10), E1825 (SCI).
https://pubmed.ncbi.nlm.nih.gov/33036420/
40. Tse-En Wang; Yu-Hua Lai; Kai-Chien Yang; Sung-Jan Lin; Chih-Lin Chen; Pei-Shiue
Tsai* Counteracting Cisplatin-induced Testicular Damages by Natural Polyphenol
Constituent Honokiol. Antioxidants 2020 Aug. 9, 9(8):723 (SCI).
https://pubmed.ncbi.nlm.nih.gov/32784851/
​
39. Yu-Ting Hsu; Ching-Ho Wu; Chun-Yuan Chao; Yu-Syuan Wei; Yen-Chen Chang; Yi-Ting
Chen; Shuei-Liong Lin; Su-Yi Tsai; Ya-Jane Lee; Pei-Shiue Tsai* Hypochlorite-induced
Porcine Model of Peritoneal Fibrosis Through The Activation of IL1β-CX3CL1-TGFβ1
Signal Axis. Scientific Reports 2020 July 13 10(1):11496 (SCI).
https://pubmed.ncbi.nlm.nih.gov/32661265/
​
38. Chun-Yuan Chao; Ching-Ho Wu; Yi-Ting Chen; Shuei-Liong Lin; Pei-Shiue Tsai*
Establishment of Hypochlorite-induced Porcine Model of Peritoneal Fibrosis.
Nephrology Dialysis Transplantation 2020 May 35:(3) gfaa142.P1205 (SCI).
​
37. Jing, Hwei; Hsu, Wei-Li; Wu, Vin-Cent; Tsai, Han-Ju; Tsai, Shang-Feng; Tsai, Pei-Shiue; Lai, Tai-Shuan; Lee, Ya-Jane*. Urine hemojuvelin in cats with naturally occurring kidney
diseases. Journal of Veterinary Internal Medicine 2020 Apr 23. doi:
10.1111/jvim.15781(SCI).
https://www.ncbi.nlm.nih.gov/pubmed/32324955
​
36. Chia-Yu Chang; Wei-Ting Hsu; Pei-Shiue Tsai; Chi-Min Chen; Ivan-Chen Cheng; Yu-Chan
Chao; Hui-Wen Chang*. Oral Administration of Porcine Epidemic Diarrhea Virus Spike
Protein Expressing in Silkworm Pupae Failed to Elicit Immune Responses in Pigs. AMB
Express 2020 Jan 28th 10(1):20(SCI).
https://www.ncbi.nlm.nih.gov/pubmed/31993764
2019
35. Ju-Yi Peng; Yi-Bing Horng; Ching-Ho Wu; Chia-Yu Chang; Yen-Chen Chang; Pei-Shiue
Tsai; Chian-Ren Jeng; Yeong-Hsiang Cheng; Hui-Wen Chang*. Evaluation of Antiviral
Activity of Bacillus licheniformis-fermented Products Against Porcine Epidemic Diarrhea
Virus. AMB Express 2019 Dec. 3;9(1):191 (SCI).
https://www.ncbi.nlm.nih.gov/pubmed/31797149
​
34. Halimeh Mobarak; Mohammad Heidarpour; Pei-Shiue Jason Tsai; Aysa Rezabakhsh;
Reza Rahbarghazi; Mohammad Nouri; Mahdi Mahdipou*. Autologous mitochondrial
microinjection; a strategy to improve the oocyte quality and subsequent reproductive
outcome during aging. Cell & Bioscience 2019 Nov 29. 9:95 (SCI).
https://www.ncbi.nlm.nih.gov/pubmed/31798829
​
33. Chia-Yu Chang; Ju-Yi Peng; Yun-Han Cheng; Yen-Chen Chang; Yen-Tse Wu; Pei-Shiue
Tsai; Hue-Ying Chiou; Chian-Ren Jeng; Hui-Wen Chang*. Development and Comparison
of Enzyme-linked Immunosorbent Assays Based on Recombinant Trimeric Full-length
and Truncated Spike Proteins for Detecting Antibodies Against Porcine Epidemic
Diarrhea Virus. BMC Veterinary Research 2019 Nov 27. 15(1):421 (SCI).
https://www.ncbi.nlm.nih.gov/pubmed/31775769
​
32. Hung-Ting Liu, Tse-En Wang, Yu-Ting Hsu, Chi-Chung Chou, Kai-Hung Huang, Cheng-
Chih Hsu, Hong-Jen Liang, Hui-Wen Chang, Tzong-Huei Lee, Pei-Shiue Tsai*.
Nanoparticulated Honokiol Mitigates Cisplatin-Induced Chronic Kidney Injury By
Maintaining Mitochondria Antioxidant Capacity And Reducing Caspase 3-Associated
Cellular Apoptosis. Antioxidants 2019 Oct. 7 8(10), piiE466 (SCI).
https://www.ncbi.nlm.nih.gov/pubmed/31600935
​
31. Po-Han Wu, Wei-Li Hsu, Pei-Shiue Jason Tsai, Vin-Cent Wu, Han-Ju Tsai, Ya-Jane Lee*.
Identification of urine neutrophil gelatinase-associated lipocalin molecular forms and
their association with different urinary diseases in cats. BMC Veterinary Research
2019 15:306 (SCI).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712848/
​
30. Shahin Ahmadian, Sepideh Sheshpari, Mahdi Mahdipour, Mohammad Pazhang, Pei-
Shiue Jason Tsai, Mohammad Nouri, Reza Rahbarghazi, Mahnaz Shahnazi*. Toxic effects
of VCD on kidney and liver tissues: a histopathological and biochemical study.
BMC Research Notes 2019 12:446 (SCI).
https://www.ncbi.nlm.nih.gov/pubmed/31331386
​
29. Chia-Yu Chang, Ivan-Chen Cheng, Yen-Chen Chang, Pei-Shiue Tsai , Seiu-Yu Lai, Yu-
Liang Huang, Chian-Ren Jeng, Victor Fei Pang & Hui-Wen Chang*. Identification of
Neutralizing Monoclonal Antibodies Targeting Novel Conformational Epitopes of the
Porcine Epidemic Diarrhoea Virus Spike Protein. Scientific Reports 2019 9:2529 (SCI).
https://www.ncbi.nlm.nih.gov/pubmed/30792462
​
2018
28. Tse-En Wang, Sheng-Hsiang Li, Shiori Minabe, Amanda Anderson, Matt Dun, Kei-Ichiro Maeda, Fuko Matsuda, Hui-Wen Chang, Brett Nixon, Pei-Shiue Jason Tsai*. Mouse Quiescin Sulfhydryl Oxidases Exhibit Distinct Epididymal Luminal Distribution With Segment-Specific Sperm Surface Associations. Biology of Reproduction 2018 Nov.
99(5)1022-1033, ioy125 (SCI). 2018 Nov. Biology of Reproduction, Cover Story
https://www.ncbi.nlm.nih.gov/pubmed/29800099
27. Chi-Fei Kao, Hue-Ying Chiou, Yen-Chen Chang, Cheng-Shun Hsueh, Chian-Ren Jeng,
Pei-Shiue Tsai, Ivan-Chen Cheng, Victor Fei Pang, Hui-Wen Chang*. Characterization of
Immunoprotection Induced by a cDNA Clone Derived from the Attenuated Taiwan
Porcine Epidemic Diarrhea Virus Pintung 52 Strain. Viruses 2018 Oct 4;10(10). pii:
E543 (SCI).
https://www.ncbi.nlm.nih.gov/pubmed/30287770
​
26. Ru-Yi Peng, Chia-Yu Chang, Chi-Fei Kao, Yen-Chen Chang, Cheng-Shun Hsueh, Chian-
Ren Jeng, Ivan-Chen Cheng, Victor Fei Pang, Pei-Shiue Tsai, Hui-Wen Chang*. Different
Intestinal Tropism of the G2b Taiwan Porcine Epidemic Diarrhea Virus-Pintung 52 Strain
in Conventional 7-Day-Old Piglets. The Veterinary Journal. 2018, 237: 69-75 (SCI).
https://www.ncbi.nlm.nih.gov/pubmed/30089548
​
25. Chang YC, Chang CY, Tsai PS, Chiou HY, Jeng CR, Pang VF, Chang HW*. Efficacy of the
Heat-Labile Enterotoxin B Subunit-Adjuvanted Parenteral Porcine Epidemic Diarrhea
Virus Trimeric Spike Subunit Vaccine in Pigs. Applied Microbiology and
Biotechnology. 2018 102(17):7499-7507 (SCI).
https://www.ncbi.nlm.nih.gov/pubmed/29961099
​
24. Tse-En Joan Wang, Hung-Ting Liu, Yu-Hua Lai, Tong-Rong Jan, Naohiro Nomura, Hui-
Wen Chang, Chi-Chung Chou, Ya-Jane Lee, Pei-Shiue Jason Tsai*. Honokiol, a Natural
Compound of Polyphenol, Attenuates Cisplatin-Induced Acute Cytotoxicity In Renal
Epithelial Cells Through Cellular Oxidative Stress And Cytoskeleton Modulations.
Frontiers in Pharmacology 2018 9:357 (SCI).
https://www.ncbi.nlm.nih.gov/pubmed/29755347
​
23. Yu JF, Lai YH, Wang TE, Wei YS, Chang YJ, Li SH, Chin SC, Joshi R, Chang HW,
Tsai PS*. The effects of Type I Collagenase on the Degelification of Chimpanzee (Pan
troglodytes) Semen Plug and Sperm Quality. BMC Veterinary Research 2018 Feb
27;14(1):58 (SCI)
https://www.ncbi.nlm.nih.gov/pubmed/29482549
​
22. Chen CN, Chou CC, Tsai PSJ, Lee YJ*. Plasma indoxyl sulfate concentration
predicts progression of chronic kidney disease in dogs and cats. The Veterinary
Journal 2018 232:33-39 (SCI)
https://www.ncbi.nlm.nih.gov/pubmed/29428089
​
2017
21. Cham TC, Chang YC, Tsai PS, Wu CH, Chen HW, Jeng CR, Pang F, Chang HW*.
Determination of cell tropism of serotype feline infectious peritonitis virus using the spike
affinity histochemistry in paraffin-embedded tissues. Microbiology and Immunology
2017 July 4:12498. (SCI)
https://www.ncbi.nlm.nih.gov/pubmed/28675506
​
20. Kuo YW, Joshi R, Wang TE, Chang HW, Li SH, Hsiao JN, Tsai PSJ*. Identification,
Characterisation and Purification of Porcine Quiescin Q6 Sulfhydryl Oxidase 2
Protein. BMC Veterinary Research 2017 June 29;13(1):205. (SCI)
https://www.ncbi.nlm.nih.gov/pubmed/28662655
​
19. Chang YC, Kao CF, Chang CY, Jeng CR, Tsai PS, Pang VF, Chiou HY, Peng JY, Cheng IC,
Chang HW*. Evaluation and Comparison of the Pathogenicity and Host Immune
Responses Induced by a G2b Taiwan Porcine Epidemic Diarrhea Virus (Strain Pintung
52) and Its Highly Cell-Culture Passaged Strain in Conventional Week Old Pigs. Viruses
2017, May 19;9(5). pii: E121. (SCI)
https://www.ncbi.nlm.nih.gov/pubmed/28534849
​
18. Wang TE, Lai YH, Tsai PS*. Functional Involvement of Reproductive Tracts In Sperm
Physiology. Open Access Journal of Veterinary Science and Research 2017, 2:1,
000125.
https://medwinpublishers.com/OAJVSR/OAJVSR16000125.pdf
​
17. Liu HT, Kuo YW, Chang HW, Lee YJ, Tsai PS*. Arginine Vasopressin Promotes
Redistribution of Adhesion Junction Protein E-Cadherin in Kidney Epithelial Cells.
Taiwan Veterinary Journal 2017, 43:3,1-10.
http://www.worldscientific.com/doi/pdfplus/10.1142/S1682648517500020?src=recsys
​
16. Liu HT, Chen LT, Chuang TF, Chang HW, Kao HH, Tsai PS*. The Effects of Vasopressin
on the Progression of Chronic Kidney Disease and Its Potential Treatment Using
Vasopressin Receptor Antagonists in the Field of Veterinary Medicine. Taiwan
Veterinary Journal 2017, 43:1, 23-28.
http://www.worldscientific.com/doi/pdfplus/10.1142/S1682648515300051?src=recsys
​
2016
15. Ching Yang, Yen Chen Chang, Chia Yu Chang, Pei Shiue Tsai, Chian Ren Jeng,
Victor Fei P ang, Ivan Chen Cheng and Hui Wen Chang*. Identification Of a Highly
Transfectable Cell Line Permissive To Porcine Epidemic Diarrhea Virus Infection
And Replication. Taiwan Veterinary Journal 2016, 42:4, 1-7.
http://www.worldscientific.com/doi/pdfplus/10.1142/S1682648515500286
14. Kuo YW, Li SH, Maeda KI, Gadella BM, Tsai PS*. Roles of Reproductive Tract on
Modifications of Sperm Membrane Surface. Journal of Reproduction and
Development 2016 62:4, 337-343. (SCI).
http://www.ncbi.nlm.nih.gov/pubmed/27009019
13. Kuo YW, Liu HT, Li SH, Maeda KI, Gadella BM, Tsai PS*. The involvement of epididymal
secretory proteins in the selection process of sperm cells. Molecular Reproduction
and Development 2016 Feb 8. doi: 10.1002/mrd.22622. (SCI)."The Art of Science"
cover.
http://www.ncbi.nlm.nih.gov/pubmed/26854495
2015
12. Chiou HY, Hung YL, Deng MC, Chang CY, Jeng CR, Tsai PS, Yang C, Pang VF, Chang
HW*. Phylogenetic Analysis of the Spike (S) Gene of the New Variants of Porcine
Epidemic Diarrhoea Virus in Taiwan. Transboundary and Emerging Diseases 2015,
April 22, doi: 10.1111/tbed.12357. (SCI).
http://www.ncbi.nlm.nih.gov/pubmed/25903998
2012
11. Florman H*, Cao WL, Jungnickel MK, Sutton KA, Tsai PS*. Coup d’oeil of Sperm.
Molecular Reproduction and Development 2012, May;79(5):Fm i. doi:
10.1002/mrd.22039. (SCI).
http://www.ncbi.nlm.nih.gov/pubmed/22508555
10. Tsai PS, Brewis IA, J. Van Maaren, Gadella BM*. Involvement Of Complexin 2 in Docking,
Locking and Unlocking of diffeent SNARE complexes in induced Acrosome
Exocytosis PLoS One. 2012;7(3):e32603. doi: 10.1371/journal.pone.0032603. Epub 2012
Mar 6 (SCI).
http://www.ncbi.nlm.nih.gov/pubmed/22412896
2011
9. Tsai PS, Van Haeften T, Gadella BM*. Preparation of the cortical reaction: maturation
dependent migration of SNARE proteins, clathrin and complexin to the porcine oocyte’s
surface blocks membrane traffic until fertilization. Biology of Reproduction 2011,
84:327-335. (SCI).
http://www.ncbi.nlm.nih.gov/pubmed/20944080
2010
8. Tsai PS, Garcia-Gil N, Colenbrander B, Van Haeften T, Gadella BM*. How pig sperm
prepares to fertilize: acrosome docking and priming to the plasma membrane. PLoS ONE
2010 Jun 18;5(6):e11204. (SCI). Citation>50
http://www.ncbi.nlm.nih.gov/pubmed/20585455
2009
7. Tsai PS, Gadella BM*. Molecular kinetics of proteins at the surface of porcine sperm before
and during fertilization. Soc. Reprod. Fertil. Suppl. 2009;66:23-36. (SCI).
http://www.ncbi.nlm.nih.gov/pubmed/19848264
2008
6. Gadella BM, Tsai PS, Boerke A, Brewis IA*. Sperm head membrane reorganisation during
capacitation. International Journal of Developmental Biology 2008;52(5-6):473-
80. (SCI).
http://www.ncbi.nlm.nih.gov/pubmed/18649260 Citation>140
​
5. Boerke A, Tsai PS, Garcia-Gil N, Brewis IA, Gadella BM*. Capacitation-dependent
reorganization of microdomains in the apical sperm head plasma membrane Functional
relationship with zona binding and the zona-induced acrosome reaction. Theriogenology
2008 Nov;70(8):1188-96. (SCI). Citation>60
http://www.ncbi.nlm.nih.gov/pubmed/18640708
2007
4. Tsai PS, De Vries KJ, De Boer-Brouwer M, Garcia-Gil N, Van Gestel RA, Colenbrander B,
Gadella BM, Van Haeften T*. Syntaxin and VAMP association with lipid rafts depends on
cholesterol depletion in capacitating sperm cells. Molecular Membrane Biology 2007
Jul-Aug;24(4):313-24. (SCI). Citation>50
http://www.ncbi.nlm.nih.gov/pubmed/17520487
2005
3. Wu JT, Tsai PS, Lee SL, Cheng FP*. Characterisation of the progesterone receptor on
canine spermatozoa. Reprod. Fertil. Dev. 2005 17(7):733-741. (SCI).
http://www.ncbi.nlm.nih.gov/pubmed/16364228
2. Tsai PS, Nielen M., van der Horst GTJ, Colenbrander B., Heesterbeek JAP, Fentener van
Vlissingen JM*. The effect of DNA repair defects on reproductive performance in
nucleotide excision repair (NER) mouse models: An epidemiological approach.
Transgenic Research 2005 14:845-857. (SCI).
http://www.ncbi.nlm.nih.gov/pubmed/16315091